Ethical considerations in Biosecurity encompass a fine balance between safeguarding public health and respecting an individual’s humane rights. Implementing robust measures to prevent misuse of biological agents raises great concerns about potential discrimination, unintended consequences, and privacy. The right balance requires great and transparent communication, informed consent, and making sure that the biosecurity measures prioritize the public’s safety without defeating the freedoms. Ethical frameworks should be able to guide policy decisions, address questions of access to such sensitive information, monitor different practices, and the potential of stigmatization of individuals. This establishes a strong ethical foundation in biosecurity measures. It is essential to foster the public’s trust, uphold humane rights, and navigate the complex interplay between protecting society from biological threats and respecting the autonomy of individuals.