Romanov Part A<\/p>\n\n\n\n
Part 1http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0004<\/p>\n\n\n\n
The Romanov\u2019s were a family of the last Russian monarchy.<\/p>\n\n\n\n
2. Briefly outline the Romanov Lineage.<\/p>\n\n\n\n
Nicholas the first married Alexandra Hedorovna. They had two kids Alexander the second who<\/p>\n\n\n\n
was married to Maria Alexandrovna. They then had Nicholas the second and he later married<\/p>\n\n\n\n
Alexandra Fedorovna. They had 5 children, Olga, Tatiana, Maria, Anastasia, and Alexei.<\/p>\n\n\n\n
3. Nicholas 2 was the last Romanov to hold the power in Russia. What was his title?<\/p>\n\n\n\n
He was king Tsar Nicholas the second because his brother Duke Michael declined the throne.<\/p>\n\n\n\n
4. What happened to Nicholas 2? Why ( from a geopolitical View)? Who then took control?<\/p>\n\n\n\n
Nicholas the second, his family, and staff were held in exile in Yekaterinburg, Russia.<\/p>\n\n\n\n
With the Tsar being king they were held by the Ural Soviets.<\/p>\n\n\n\n
5. Describe the Family of Nicholas 2. What happened to them?<\/p>\n\n\n\n
The Nicholas family consisted of him and his wife. Who had 4 daughters and 1 son. They were all captured and killed by the soviets.<\/p>\n\n\n\n
Part 2 Hemophilia<\/p>\n\n\n\n
6. How was Nicholas 2 wife, Alex, related to Queen Victoria of England?<\/p>\n\n\n\n
Nicholas\u2019 wife is the grandchild of Queen Victoria of England.<\/p>\n\n\n\n
Both Queen Victoria and Alex are designated as being carries for Hemophilia.<\/p>\n\n\n\n
7. In a couple sentences, describe the disease Hemophilia.<\/p>\n\n\n\n
Hemophilia is an Inherited bleeding disorder. The affected blood does not clot properly. This<\/p>\n\n\n\n
can be deadly, it can cause spontaneous bleeding after injury or surgery. This disease occurs<\/p>\n\n\n\n
because people lack factor 8 and 9 protein in their blood. Hemophilia is a mutation or change<\/p>\n\n\n\n
the clotting factors genes. The genes are located on the X chromosome.<\/p>\n\n\n\n
Source for 8-10 http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20557352<\/a><\/p>\n\n\n\n 8.What type of Hemophilia (A or B) is ( probably) represented in the pedigree chart?<\/p>\n\n\n\n Hemophilia B is the represented disease. With a mutation in the F9 gene.<\/p>\n\n\n\n 9. The Romanov\u2019s son, Alexis, had Hemophilia. Describe how Alexis genetically acquired<\/p>\n\n\n\n Hemophilia. ( Use a Punnett square)<\/p>\n\n\n\n A male has XY chromosomes, a female has both XX chromosomes. While his father Nicholas did not have the gene mutation for the F8 or F9 protein his mother was a carrier of Hemophilia.<\/p>\n\n\n\n Which means he as the only son would be born with hemophilia because the only X<\/p>\n\n\n\n chromosome passed down from the mother was affected.<\/p>\n\n\n\n 10. Using a Punnett square, explain why only males in the pedigree chart have Hemophilia.<\/p>\n\n\n\n Only males in the pedigree chart will have full hemophilia because of the only affected X<\/p>\n\n\n\n chromosome that can be passed down from mother. Males when they have children can only<\/p>\n\n\n\n pass down the Y chromosome giving the chance of having a son. With that being said, the male<\/p>\n\n\n\n were to have the 1 in 2 chance of being the son with Hemophilia.<\/p>\n\n\n\n 11. Is it possible for a female to inherit Hemophilia, and if so, how?<\/p>\n\n\n\n A female can inherit Hemophilia, yet that would mean the mother would have hemophilia or be<\/p>\n\n\n\n Heterozygous and the father would have Hemophilia. The father passes his only X chromosome<\/p>\n\n\n\n down to all his daughters. Which means He would have to have hemophilia for any of his<\/p>\n\n\n\n daughters to get the trait. ( Males have XY chromosomes ^). The mother would pass down the<\/p>\n\n\n\n carrier or heterozygous X chromosome as well. Which means 50% of their children would have<\/p>\n\n\n\n Hemophilia and 1 or 4 would be a carrier. One daughter and one sone would have hemophilia<\/p>\n\n\n\n and on daughter would be a carrier. The sons would have a 1 in 2 chance of getting Hemophilia.<\/p>\n\n\n\n 12. None of Alexis\u2019 sisters are shown to have Hemophilia. Using only the tools available at the time they lived, how could it have been determined whether they were carries like their mother?<\/p>\n\n\n\n They would have had to had a family member show the symptoms of hemophilia and<\/p>\n\n\n\n determined the inheritability. (?)<\/p>\n\n\n\n 13. Using the Punnett square, what is the probability the daughter of a mother who is a carrier and a father who does not have the disease, will be a carrier?<\/p>\n\n\n\n The daughter has a 50% chance of being the carrier out the daughter<\/p>\n\n\n\n 14. Using a Punnett square, what is the probability that 4 daughter of a mother who is carrier and a father who does not have the disease, will be a carrier?<\/p>\n\n\n\n .5 x .5 x .5 x .5 = 6.25 % because The daughters would have a 50% chance of getting passed<\/p>\n\n\n\n down the carrier gene.<\/p>\n\n\n\n 15. Using a Punnett square, explain why none of Alexi\u2019s sisters had Hemophilia<\/p>\n\n\n\n The X chromosome passed down to them by the father does not have the mutation and the X chromosome they received from their mother was a 50% chance of being the one with the<\/p>\n\n\n\n factor 8 or 9 mutation which none of theme received.<\/p>\n\n\n\n 16. Some Historians speculate that Alexis\u2019 Hemophilia condition could have led to the Russian<\/p>\n\n\n\n Revolution. Explain. ( Look up the faith healer Rasputin)<\/p>\n\n\n\n Part II: Hemophilia<\/p>\n\n\n\n The pedigree chart below comes from the Module powerpoint lecture notes.<\/p>\n\n\n\n Use the following source for the questions 2:<\/p>\n\n\n\n http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20557352<\/p>\n\n\n\n (You won\u2019t be able to access the entire article, but the abstract will give you the information you need to answer the questions.)<\/p>\n\n\n\n 1. Using your knowledge from Module 4, on what chromosome is the gene that causes hemophilia?<\/p>\n\n\n\n The Hemophilia gene is on chromosome X<\/p>\n\n\n\n 2. Describe the mutation that apparently caused hemophilia in Alix, (and probably all of the<\/p>\n\n\n\n European families that had hemophilia). <\/p>\n\n\n\n The mutation was of the acceptor site of exon 4 in the F9 gene. <\/p>\n\n\n\n 3.Using your knowledge from Module 7, describe how the mutation you described in #10 could result in a faulty gene product. <\/p>\n\n\n\n The F9 gene provides instruction for making clotting factors proteins in order for blood to clot. With this mutation a faulty gene product it produced.<\/p>\n\n\n\n