In this course, we discussed the processes that B and T cells, which are crucial players in the adaptive immune system, go through to maintain a properly functioning immune response while avoiding harmful consequences such as autoimmunity. In the thymus during maturation, T lymphocytes are subject to both positive and negative selection. Positive selection promotes the survival of T lymphocytes that recognize self-major histocompatibility complex (MHC) molecules. Strongly reacting T cells to self-antigens are eliminated by negative selection, which stops autoreactive T cells from developing and attacking the body’s own tissues. Similar to negative selection in T cells, growing B cells that strongly react to self-antigens may suffer clonal deletion. Autoreactive B cells are eliminated or turned inactive through this mechanism, which stops the body from producing dangerous antibodies against itself. This improved my comprehension of the steps that B and T cells take to guarantee an effective immune response and prevent autoimmune diseases like type 1 diabetes. I knew very little about how the immune system functions before taking this class. Understanding B and cell control has helped me grasp how the immune system works and has helped me become a better student overall. My ability to take care of my health and maintain a strong immune system has improved as a result of taking this course.