A primary article is written by original authors and used to establish something. The paperwork is original work that aims to establish a new idea, whether that be a research method or a hypothesis. This usually means that something has been tested and will include results. It is generally an analysis that will warrant further discussion. It does not contain discussion about other works or analysis of other articles because it is original.

On the other hand, there are review articles that further analyze other ideas that have been written about. It allows other people to get introduced to a topic before they read the primary article. It can be a generalization of differing opinions and literature in one conclusive place on a topic. This prevents someone from having to read many primary articles about a topic when they are searching for a more preliminary overview. It typically does not have a strong results or conclusion.

Scientific peer review is the process where someone will write a review article or paper about a specific topic, then the draft will be sent to an editor to see if it will be a good fit for the journal for which they are applying. The article, if approved by the editor is sent to a team of educated persons who work in a similar field who will review and ask questions about if the work is valuable, original, interesting, and more. Once the peer review team approves the article, it goes back to the editor for a final approval process where they will place it in the journal or not. The peer review process, if approved will cause the article to be marked as peer reviewed and raise the validity of the article.

After reviewing the two articles, I have concluded that Base editing of hematopoietic stem cells rescues sickle cell disease in mice is a primary article because it reports analyses and results. The article discusses using a custom adenine base editor to convert the sickle cell disease allele. This reports the findings. This is different than the review article, Hematopoietic Stem Cell Gene-Addition/Editing Therapy Sickle Cell Disease. This article discusses the meaning of the results found by research conducted on autologous hematopoietic stem cell targeted gene therapy. The article summarizes the results anddiscusses them, rather than reporting them like a primary article would.