The principles of science are deeply connected with cybersecurity. Empirical evidence and testing which are fundamental to science, guide the evaluation of security measures through simulations and real-world trials. Hypothesis testing in cybersecurity involves identifying and investigating potential threats and vulnerabilities. Predictive models and data analysis help anticipate and manage risks, while continuous innovation ensures that security practices evolve in response to emerging threats. Reproducibility and peer review validate cybersecurity solutions and research findings. Applying systems thinking in science to cybersecurity allows for a better understanding of complex interactions within cybersecurity systems, ensuring comprehensive protection. Applying scientific principles helps create effective, evidence-based strategies for safeguarding information and systems.