Primary articles are reports of scientific findings that are original to the knowledgeable publishers. These articles aim to advance fields in science and focus on new data and analysis. The content shares direct scientific knowledge on new discoveries, including an explanation of the procedure and results. The concept is that the discoveries can be replicated by other experts via following the procedures outlined in the primary article. Normally, the discoveries are credited through evaluation by other related experts, identified as peer-reviewed.

Review articles summarize existing scientific literature on specific topics. Their main goal is to bring together published research and provide an overview of a scientific subject. While they might not cover every detail, these articles are helpful learning tools that give useful insights into the current knowledge in the field.

When a researcher intends to submit their work to a scholarly journal, they must follow a process known as peer review. The researcher prepares a paper outlining their procedures and results, while keeping the target publication in mind. After submission, the journal editor evaluates whether the research aligns with the publication’s focus. If deemed suitable, the research paper is then sent to experts in the relevant field for further review. The experts evaluate the research by posing a series of questions aimed at assessing its originality, significance, logic, and methodology. This step is where the term ‘peer’ in ‘peer review’ is founded, as reviewers are expert peers in same field as the submitting researcher.  Next, if the research receives approval from the experts, it is

then returned to the editor, typically with recommendations for revisions. This process is very selective and once research is back to the editor it is still unlikely to be officially approved. After months or even years, if the editor approves the research following revisions, it will be published and officially designated as peer-reviewed.

From the provided articles, the primary article is, “Base editing of hematopoietic stem cells rescues sickle cell disease in mice,” as it details a specific procedure from a first-person perspective, presenting the results, data, and participants. The review article is “Hematopoietic Stem Cell Gene-Addition/Editing Therapy in Sickle Cell Disease” as it discusses multiple advancements in treating sickle cell disease, including citations to credit the information, and it does not provide detailed descriptions for conduction of procedures.