In order to address the growing threat of cyberattacks on biological and medical systems, a new field called “cyberbiosecurity” has been proposed. Many vulnerabilities have been brought to light in recent years by a slew of conferences, public discussions, commentary, and publications. Though these are essential beginnings, they do not provide a systematic framework for advancing the analysis, research, development, testing, and evaluation, and implementation of scientific, technological, standards of practice, policy, or even regulatory or legal considerations for protecting the bioeconomy. In addition, there is a lack of understanding between biosecurity and cybersecurity professionals regarding each other’s fields, areas of competence, viewpoints, objectives, and potential areas of mutually supported opportunity. Formal, fruitful, and ongoing partnerships may be fostered via the development, dissemination, and advancement of a new field. Cyberbiosecurity’s extension to cover biomanufacturing is discussed, with the latter substantiated by a thorough investigation of a biomanufacturing plant. The authors provide some suggestions for getting Cyberbiosecurity off the ground and moving in the direction of becoming a formalized, well-attended field of study and successful industry. With more unity in the cyber and biological sectors, the Fourth Industrial Revolution has reached its pinnacle of development, shortening the gap between the world’s momentous advances in scientific discoveries, known as the Industrial Revolution. The current study uses a descriptive-analytical approach to investigate security threats in the bio-cyber sector, highlighting how cyberspace has become an undeniable platform in various fields of biological sciences and introducing this increasingly dependent situation as a serious challenge to science and technology at the height of the Fourth Industrial Revolution.