Publications

  • Silkuniene, G., Mangalanathan, U. M., Rossi, A., Mollica, P. A., Pakhomov, A. G., & Pakhomova, O. (2023). Identification of Proteins Involved in Cell Membrane Permeabilization by Nanosecond Electric Pulses (nsEP). International Journal of Molecular Sciences, 24(11), 9191.
  • Kim, V., Semenov, I., Kiester, A. S., Keppler, M. A., Ibey, B. L., Bixler, J. N., Colunga Biancatelli, R.M., & Pakhomov, A. G. (2023). Control of the Electroporation Efficiency of Nanosecond Pulses by Swinging the Electric Field Vector Direction. International Journal of Molecular Sciences, 24(13), 10921.
  • Pakhomov, A. G., Gudvangen, E., Mangalanathan, U., Kondratiev, O., Redondo, L., & Semenov, I. (2023). Next generation CANCAN focusing for remote stimulation by nanosecond electric pulses. Bioelectrochemistry, 152, 108437.
  • Gudvangen, E., Mangalanathan, U., Semenov, I., Kiester, A. S., Keppler, M. A., Ibey, B. L., Bixler, J. N., & Pakhomov, A. G. (2023). Pulsed Electric Field Ablation of Esophageal Malignancies and Mitigating Damage to Smooth Muscle: An In Vitro Study. International Journal of Molecular Sciences, 24(3), 2854.
  • Kim, V., Semenov, I., Kiester, A. S., Keppler, M. A., Ibey, B. L., Bixler, J. N., & Pakhomov, A. G. (2023). Action spectra and mechanisms of (in) efficiency of bipolar electric pulses at electroporation. Bioelectrochemistry, 149, 108319.
  • Kiełbik, A., Sowa, P. W., Pakhomov, A. G., Gudvangen, E., Mangalanathan, U., Kulbacka, J., & Pakhomova, O. N. (2023). Urine protects urothelial cells against killing with nanosecond pulsed electric fields. Bioelectrochemistry, 149, 108289.
  • Sowa, P. W., Kiełbik, A. S., Pakhomov, A. G., Gudvangen, E., Mangalanathan, U., Adams, V., & Pakhomova, O. N. (2022). How to alleviate cardiac injury from electric shocks at the cellular level. Frontiers in Cardiovascular Medicine, 9, 1004024.
  • Silkunas M, Gudvangen E, Novickij V, Pakhomov AG, (2022). Sub-MHz bursts of nanosecond pulses excite neurons at paradoxically low electric field thresholds without membrane damage. Biochimica Et Biophysica Acta (BBA) – Biomembranes, 1864(11), 184034.
  • Gudvangen E, Kim V, Novicki V, Battista F, Pakhomov AG, (2022). Electroporation and cell killing by milli- to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation. Scientific Reports, 12(1).
  • Pakhomov AG, Gudvangen E, Xiao S, Semenov I, (2021). Interference targeting of bipolar nanosecond electric pulses for spatially focused electroporation, electrostimulation, and tissue ablation. Bioelectrochemistry, 141, 107876.
  • Kim V, Gudvangen E, Kondratiev O, Redondo L, Xiao S, Pakhomov AG, (2021). Peculiarities of Neurostimulation by Intense Nanosecond Pulsed Electric Fields: How to Avoid Firing in Peripheral Nerve Fibers. International Journal of Molecular Sciences, 22(13), 7051.
  • Kandratsyeu A, Sabaleuski U, Redondo L, Pakhomov AG (2021). Four Channel 6.5 kV, 65 A, 100 ns–100 µs Generator with Advanced Control of Pulse and Burst Protocols for Biomedical and Biotechnological Applications. Applied Sciences, 11(24), 11782.
  • Bhattacharya S, Silkunas M, Gudvangen E, Mangalanathan U, Pakhomova ON, Pakhomov AG. Ca2+ dependence and kinetics of cell membrane repair after electropermeabilization. Biochim Biophys Acta Biomembr. 2021 Nov 25;1864(2):183823.
  • Neuber JU, Pakhomov AG, Zemlin CW. Electroporation safety factor of 300 nanosecond and 10 millisecond defibrillation in Langendorff-perfused rabbit hearts. PLoS One. 2021 Sep 24;16(9):e0257287.
  • Kiester AS, Ibey BL, Coker ZN, Pakhomov AG, Bixler JN. Strobe photography mapping of cell membrane potential with nanosecond resolution. Bioelectrochemistry. 2021 Aug 13;142:107929.
  • Kim V, Gudvangen E, Kondratiev O, Redondo L, Xiao S, Pakhomov AG. Peculiarities of Neurostimulation by Intense Nanosecond Pulsed Electric Fields: How to Avoid Firing in Peripheral Nerve Fibers. Int J Mol Sci. 2021 Jun 30;22(13):7051.
  • Pakhomov AG, Gudvangen E, Xiao S, Semenov I. Interference targeting of bipolar nanosecond electric pulses for spatially focused electroporation, electrostimulation, and tissue ablation. Bioelectrochemistry. 2021 Oct;141:107876.
  • Muratori C, Silkuniene G, Mollica PA, Pakhomov AG, Pakhomova ON. The role of ESCRT-III and Annexin V in the repair of cell membrane permeabilization by the nanosecond pulsed electric field, Bioelectrochemistry. 2021 Aug;140:107837.
  • Sözer EB, Pakhomov AG, Semenov I, Casciola M, Kim V, Vernier PT, Zemlin CW. Analysis of electrostimulation and electroporation by high repetition rate bursts of nanosecond stimuli. Bioelectrochemistry. 2021 Aug;140:107811.
  • Pakhomov AG, Pakhomova ON. The interplay of excitation and electroporation in nanosecond pulse stimulation. Bioelectrochemistry. 2020 Dec;136:107598.
  • Bo W, Silkunas M, Mangalanathan U, Novickij V, Casciola M, Semenov I, Xiao S, Pakhomova ON, Pakhomov AG. Probing Nanoelectroporation and Resealing of the Cell Membrane by the Entry of Ca2+ and Ba2+ Ions. Int J Mol Sci. 2020 May 11;21(9):3386. doi: 10.3390/ijms21093386. PMID: 32403282; PMCID: PMC7247012.
  • Rossi A, Pakhomova ON, Mollica PA, Casciola M, Mangalanathan U, Pakhomov AG, Muratori C. Nanosecond Pulsed Electric Fields Induce Endoplasmic Reticulum Stress Accompanied by Immunogenic Cell Death in Murine Models of Lymphoma and Colorectal Cancer. Cancers (Basel). 2019 Dec 17;11(12):2034.
  • Michel O, Pakhomov AG, Casciola M, Saczko J, Kulbacka J, Pakhomova ON. Electropermeabilization does not correlate with plasma membrane lipid oxidation. Bioelectrochemistry. 2020 Apr;132:107433.
  • Gianulis EC, Casciola M, Zhou C, Yang E, Xiao S, Pakhomov AG. Selective distant electrostimulation by synchronized bipolar nanosecond pulses. Sci Rep. 2019 Sep 11;9(1):13116.
  • Pakhomov AG, Xiao S, Novickij V, Casciola M, Semenov I, Mangalanathan U, Kim V, Zemlin C, Sozer E, Muratori C, Pakhomova ON. Excitation and electroporation by MHz bursts of nanosecond stimuli. Biochem Biophys Res Commun. 2019 Oct 22;518(4):759-764. doi: 10.1016/j.bbrc.2019.08.133. Epub 2019 Aug 28. PMID: 31472962; PMCID: PMC6758562.
  • Casciola M, Xiao S, Apollonio F, Paffi A, Liberti M, Muratori C, Pakhomov AG. Cancellation of nerve excitation by the reversal of nanosecond stimulus polarity and its relevance to the gating time of sodium channels. Cell Mol Life Sci. 2019 Nov;76(22):4539-4550. doi: 10.1007/s00018-019-03126-0. Epub 2019 May 4. PMID: 31055644.
  • Rossi A, Pakhomova ON, Pakhomov AG, Weygandt S, Bulysheva AA, Murray LE, Mollica PA, Muratori C. Mechanisms and immunogenicity of nsPEF-induced cell death in B16F10 melanoma tumors. Sci Rep. 2019 Jan 23;9(1):431. doi: 10.1038/s41598-018-36527-5. PMID: 30674926; PMCID: PMC6344591.
  • Azarov JE, Semenov I, Casciola M, Pakhomov AG. Excitation of murine cardiac myocytes by nanosecond pulsed electric field. J Cardiovasc Electrophysiol. 2019 Mar;30(3):392-401. doi: 10.1111/jce.13834. Epub 2019 Jan 17. PMID: 30582656; PMCID: PMC6422740.
  • Hristov K, Mangalanathan U, Casciola M, Pakhomova ON, Pakhomov AG. Expression of voltage-gated calcium channels augments cell susceptibility to membrane disruption by nanosecond pulsed electric field. Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2175-2183. doi: 10.1016/j.bbamem.2018.08.017. Epub 2018 Sep 1. PMID: 30409513.
  • Semenov I, Grigoryev S, Neuber JU, Zemlin CW, Pakhomova ON, Casciola M, Pakhomov AG. Excitation and injury of adult ventricular cardiomyocytes by nano- to millisecond electric shocks. Sci Rep. 2018 May 29;8(1):8233. doi: 10.1038/s41598-018-26521-2. PMID: 29844431; PMCID: PMC5974370.
  • Pakhomov AG, Grigoryev S, Semenov I, Casciola M, Jiang C, Xiao S. The second phase of bipolar, nanosecond-range electric pulses determines the electroporation efficiency. Bioelectrochemistry. 2018 Aug;122:123-133. doi: 10.1016/j.bioelechem.2018.03.014. Epub 2018 Mar 29. PMID: 29627664; PMCID: PMC5984177.
  • Semenov I, Casciola M, Ibey BL, Xiao S, Pakhomov AG. Electropermeabilization of cells by closely spaced paired nanosecond-range pulses. Bioelectrochemistry. 2018 Jun;121:135-141. doi: 10.1016/j.bioelechem.2018.01.013. Epub 2018 Jan 31. PMID: 29413863; PMCID: PMC5907791.
  • Varghese F, Neuber JU, Xie F, Philpott JM, Pakhomov AG, Zemlin CW. Low-energy defibrillation with nanosecond electric shocks. Cardiovasc Res. 2017 Dec 1;113(14):1789-1797. doi: 10.1093/cvr/cvx172. PMID: 29016714; PMCID: PMC5852636.
  • Muratori C, Pakhomov AG, Gianulis E, Meads J, Casciola M, Mollica PA, Pakhomova ON. Activation of the phospholipid scramblase TMEM16F by nanosecond pulsed electric fields (nsPEF) facilitates its diverse cytophysiological effects. J Biol Chem. 2017 Nov 24;292(47):19381-19391. doi: 10.1074/jbc.M117.803049. Epub 2017 Oct 5. PMID: 28982976; PMCID: PMC5702676.
  • Jensen SD, Khorokhorina VA, Muratori C, Pakhomov AG, Pakhomova ON. Delayed hypersensitivity to nanosecond pulsed electric field in electroporated cells. Sci Rep. 2017 Sep 8;7(1):10992. doi: 10.1038/s41598-017-10825-w. PMID: 28887559; PMCID: PMC5591300.
  • Casciola M, Xiao S, Pakhomov AG. Damage-free peripheral nerve stimulation by 12-ns pulsed electric field. Sci Rep. 2017 Sep 5;7(1):10453. doi: 10.1038/s41598-017-10282-5. PMID: 28874684; PMCID: PMC5585227.
  • Gianulis EC, Casciola M, Xiao S, Pakhomova ON, Pakhomov AG. Electropermeabilization by uni- or bipolar nanosecond electric pulses: The impact of extracellular conductivity. Bioelectrochemistry. 2018 Feb;119:10-19. doi: 10.1016/j.bioelechem.2017.08.005. Epub 2017 Aug 25. PMID: 28865240.
  • Muratori C, Pakhomov AG, Heller L, Casciola M, Gianulis E, Grigoryev S, Xiao S, Pakhomova ON. Electrosensitization Increases Antitumor Effectiveness of Nanosecond Pulsed Electric Fields In Vivo. Technol Cancer Res Treat. 2017 Dec;16(6):987-996. doi: 10.1177/1533034617712397. Epub 2017 Jun 6. PMID:28585492; PMCID: PMC5762058.
  • Merla C, Pakhomov AG, Semenov I, Vernier PT. Frequency spectrum of induced transmembrane potential and permeabilization efficacy of bipolar electric pulses. Biochim Biophys Acta Biomembr. 2017 Jul;1859(7):1282-1290. doi:10.1016/j.bbamem.2017.04.014. Epub 2017 Apr 18. PMID: 28432034.
  • Pakhomov AG, Semenov I, Casciola M, Xiao S. Neuronal excitation and permeabilization by 200-ns pulsed electric field: An optical membrane potential study with FluoVolt dye. Biochim Biophys Acta Biomembr. 2017 Jul;1859(7):1273-1281. doi: 0.1016/j.bbamem.2017.04.016. Epub 2017 Apr 18. PMID: 28432032; PMCID: PMC5484080.
  • Muratori C, Pakhomov AG, Pakhomova ON. Effect of Cooling On Cell Volume and Viability After Nanoelectroporation. J Membr Biol. 2017 Apr;250(2):217-224. doi: 10.1007/s00232-017-9952-3. Epub 2017 Feb 27. PMID: 28243693.
  • Gianulis EC, Labib C, Saulis G, Novickij V, Pakhomova ON, Pakhomov AG. Selective susceptibility to nanosecond pulsed electric field (nsPEF) across different human cell types. Cell Mol Life Sci. 2017 May;74(9):1741-1754. doi: 10.1007/s00018-016-2434-4. Epub 2016 Dec 16. PMID: 27986976; PMCID: PMC7024567.
  • Muratori C, Pakhomov AG, Gianulis EC, Jensen SD, Pakhomova ON. The cytotoxic synergy of nanosecond electric pulses and low temperature leads to apoptosis. Sci Rep. 2016 Nov 11;6:36835. doi: 10.1038/srep36835. PMID: 27833151; PMCID: PMC5104977.
  • Dermol J, Pakhomova ON, Pakhomov AG, Miklavčič D. Cell Electrosensitization Exists Only in Certain Electroporation Buffers. PLoS One. 2016 Jul 25;11(7):e0159434. doi: 0.1371/journal.pone.0159434. PMID: 27454174; PMCID: PMC4959715.
  • Xiao S, Semenov I, Petrella R, Pakhomov AG, Schoenbach KH. A subnanosecond electric pulse exposure system for biological cells. Med Biol Eng Comput. 2017 Jul;55(7):1063-1072. doi: 10.1007/s11517-016-1516-7. Epub 2016 May 13. PMID: 27177544; PMCID: PMC5884115.
  • Semenov I, Xiao S, Pakhomov AG. Electroporation by subnanosecond pulses. Version 2. Biochem Biophys Rep. 2016 Jul;6:253-259. doi: 10.1016/j.bbrep.2016.05.002. Epub 2016 May 3. PMID: 27482547; PMCID: PMC4964847.
  • Muratori C, Pakhomov AG, Xiao S, Pakhomova ON. Electrosensitization assists cell ablation by nanosecond pulsed electric field in 3D cultures. Sci Rep. 2016 Mar 18;6:23225. doi: 10.1038/srep23225. PMID: 26987779; PMCID: PMC4796786.
  • Xie F, Varghese F, Pakhomov AG, Semenov I, Xiao S, Philpott J, Zemlin C. Ablation of Myocardial Tissue With Nanosecond Pulsed Electric Fields. PLoS One. 2015 Dec 14;10(12):e0144833. doi: 10.1371/journal.pone.0144833. PMID: 26658139; PMCID: PMC4687652.
  • Edelblute CM, Pakhomova ON, Li F, Hargrave BY, Heller LC. Donor platelet plasma components inactivate sensitive and multidrug resistant Acinetobacter baumannii isolates. Pathog Dis. 2015 Dec;73(9):ftv095. doi: 10.1093/femspd/ftv095. Epub 2015 Oct 23. PMID: 26500225.
  • Gianulis EC, Lee J, Jiang C, Xiao S, Ibey BL, Pakhomov AG. Electroporation of mammalian cells by nanosecond electric field oscillations and its inhibition by the electric field reversal. Sci Rep. 2015 Sep 8;5:13818. doi: 10.1038/srep13818. PMID: 26348662; PMCID: PMC4562301.
  • Semenov I, Zemlin C, Pakhomova ON, Xiao S, Pakhomov AG. Diffuse, non-polar electropermeabilization and reduced propidium uptake distinguish the effect of nanosecond electric pulses. Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2118-25. doi: 10.1016/j.bbamem.2015.06.018. Epub 2015 Jun 22. PMID: 26112464; PMCID: PMC4554928.
  • Semenov I, Xiao S, Kang D, Schoenbach KH, Pakhomov AG. Cell stimulation and calcium mobilization by picosecond electric pulses. Bioelectrochemistry. 2015 Oct;105:65-71. doi: 10.1016/j.bioelechem.2015.05.013. Epub 2015 May 20. PMID: 26011130; PMCID: PMC4499485.
  • Vernier PT, Levine ZA, Ho MC, Xiao S, Semenov I, Pakhomov AG. Picosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes. J Membr Biol. 2015 Oct; 248(5):837-47. doi: 10.1007/s00232-015-9788-7. Epub 2015 Mar 22. PMID: 25796485; PMCID: PMC4565733.
  • Becker A, Kannan TR, Taylor AB, Pakhomova ON, Zhang Y, Somarajan SR, Galaleldeen A, Holloway SP, Baseman JB, Hart PJ. Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5165-70. doi: 10.1073/pnas.1420308112. Epub 2015 Apr 6. PMID: 25848012; PMCID: PMC4413325.
  • Gianulis EC, Pakhomov AG. Gadolinium modifies the cell membrane to inhibit permeabilization by nanosecond electric pulses. Arch Biochem Biophys. 2015 Mar 15;570:1-7. doi: 0.1016/j.abb.2015.02.013. Epub 2015 Feb 21. PMID: 25707556; PMCID: PMC4369433.
  • Pakhomov AG, Gianulis E, Vernier PT, Semenov I, Xiao S, Pakhomova ON.Multiple nanosecond electric pulses increase the number but not the size of long-lived nanopores in the cell membrane. Biochim Biophys Acta. 2015 Apr;1848(4):958-66. doi: 10.1016/j.bbamem.2014.12.026. Epub 2015 Jan 10. PMID: 25585279; PMCID: PMC4331219.
  • Schoenbach KH, Pakhomov AG, Semenov I, Xiao S, Pakhomova ON, Ibey BL. Ion transport into cells exposed to monopolar and bipolar nanosecond pulses. Bioelectrochemistry. 2015 Jun;103:44-51. doi: 10.1016/j.bioelechem.2014.08.015. Epub 2014 Aug 29. PMID: 25212701; PMCID: PMC4345159.
  • Kannan TR, Krishnan M, Ramasamy K, Becker A, Pakhomova ON, Hart PJ, Baseman JB. Functional mapping of community-acquired respiratory distress syndrome (CARDS) toxin of Mycoplasma pneumoniae defines regions with ADP-ribosyltransferase, vacuolating and receptor-binding activities. Mol Microbiol. 2014 Aug; 93(3):568-81. doi: 10.1111/mmi.12680. Epub 2014 Jul 10. PMID: 24948331; PMCID: PMC4116743.
  • Rassokhin MA, Pakhomov AG. Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF). Cell Biochem Biophys. 2014 Jul;69(3):555-66. doi: 10.1007/s12013-014-9831-9. PMID: 24488232; PMCID: PMC4058383.
  • Pakhomova ON, Gregory B, Semenov I, Pakhomov AG. Calcium-mediated pore expansion and cell death following nanoelectroporation. Biochim Biophys Acta. 2014 Oct;1838(10):2547-54. doi: 10.1016/j.bbamem.2014.06.015. Epub 2014 Jun 28. PMID: 24978108; PMCID: PMC4125538.
  • Pakhomov AG, Semenov I, Xiao S, Pakhomova ON, Gregory B, Schoenbach KH,Ullery JC, Beier HT, Rajulapati SR, Ibey BL. Cancellation of cellular responses to nanoelectroporation by reversing the stimulus polarity. Cell Mol Life Sci. 2014 Nov;71(22):4431-41. doi: 10.1007/s00018-014-1626-z. Epub 2014 Apr 21. PMID: 24748074; PMCID: PMC4205218.
  • Pakhomov AG, Xiao S, Pakhomova ON, Semenov I, Kuipers MA, Ibey BL. Disassembly of actin structures by nanosecond pulsed electric field is a downstream effect of cell swelling. Bioelectrochemistry. 2014 Dec;100:88-95. doi: 10.1016/j.bioelechem.2014.01.004. Epub 2014 Jan 21. PMID: 24507565; PMCID: PMC4105330.
  • Ibey BL, Ullery JC, Pakhomova ON, Roth CC, Semenov I, Beier HT, Tarango M, Xiao S, Schoenbach KH, Pakhomov AG. Bipolar nanosecond electric pulses are less efficient at electropermeabilization and killing cells than monopolar pulses. Biochem Biophys Res Commun. 2014 Jan 10; 443(2):568-73. doi: 10.1016/j.bbrc.2013.12.004. Epub 2013 Dec 8. PMID: 24332942; PMCID: PMC3936343.
  • Semenov I, Xiao S, Pakhomova ON, Pakhomov AG. Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration. Cell Calcium. 2013 Sep; 54(3):145-50. doi: 10.1016/j.ceca.2013.05.008. Epub 2013 Jun 15. PMID: 23777980; PMCID: PMC3759600.
  • Pakhomova ON, Gregory BW, Semenov I, Pakhomov AG. Two modes of cell death caused by exposure to nanosecond pulsed electric field. PLoS One. 2013 Jul 23; 8(7):e70278. doi: 10.1371/journal.pone.0070278. PMID: 23894630; PMCID:PMC3720895.
  • Pakhomova ON, Gregory BW, Pakhomov AG. Facilitation of electroporative drug uptake and cell killing by electrosensitization. Version 2. J Cell Mol Med. 2013 Jan; 17(1):154-9. doi: 10.1111/j.1582-4934.2012.01658.x. Epub 2013 Jan 11. PMID: 23305510; PMCID: PMC3665946.
  • Semenov I, Xiao S, Pakhomov AG. Primary pathways of intracellular Ca(2+) mobilization by nanosecond pulsed electric field. Biochim Biophys Acta. 2013 Mar; 1828(3):981-9. doi: 0.1016/j.bbamem.2012.11.032. Epub 2012 Dec 5. PMID: 23220180; PMCID: PMC3560326.
  • Pakhomov AG. Response to “Sodium current inhibition by nanosecond pulsed electric field (nsPEF)–fact or artifact?” by Verkerk et al. Bioelectromagnetics. 2013 Feb;34(2):165-6. doi: 10.1002/bem.21756. Epub 2012 Sep 18. PMID: 22991075.
  • Pakhomova ON, Khorokhorina VA, Bowman AM, RodaitÄ—-RiÅ¡evičienÄ— R, Saulis G, Xiao S, Pakhomov AG. Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media. Arch Biochem Biophys. 2012 Nov 1;527(1):55-64. doi: 10.1016/j.abb.2012.08.004. Epub 2012 Aug 15. PMID: 22910297; PMCID: PMC3459148.
  • Rassokhin MA, Pakhomov AG. Electric field exposure triggers and guides formation of pseudopod-like blebs in U937 monocytes. J Membr Biol. 2012 Sep;245(9):521-9. doi: 10.1007/s00232-012-9433-7. Epub 2012 May 26. PMID: 22638933; PMCID: PMC3509747.
  • Nesin V, Pakhomov AG. Inhibition of voltage-gated Na(+) current by nanosecond pulsed electric field (nsPEF) is not mediated by Na(+) influx or Ca(2+) signaling. Bioelectromagnetics. 2012 Sep;33(6):443-51. doi: 10.1002/bem.21703. Epub 2012 Jan 10. PMID: 22234846; PMCID: PMC3330144.
  • Nesin V, Bowman AM, Xiao S, Pakhomov AG. Cell permeabilization and inhibition of voltage-gated Ca(2+) and Na(+) channel currents by nanosecond pulsed electric field. Bioelectromagnetics. 2012 Jul;33(5):394-404. doi: 10.1002/bem.21696. Epub 2011 Dec 28. PMID: 22213081; PMCID: PMC3336014.
  • Pakhomova ON, Gregory BW, Khorokhorina VA, Bowman AM, Xiao S, Pakhomov AG. Electroporation-induced electrosensitization. PLoS One. 2011 Feb 9;6(2):e17100. doi: 10.1371/journal.pone.0017100. PMID: 21347394; PMCID: PMC3036735.
  • Ibey BL, Roth CC, Pakhomov AG, Bernhard JA, Wilmink GJ, Pakhomova ON. Dose-dependent thresholds of 10-ns electric pulse induced plasma membrane disruption and cytotoxicity in multiple cell lines. PLoS One. 2011 Jan 26;6(1):e15642. doi: 10.1371/journal.pone.0015642. PMID: 21390200; PMCID: PMC3027629.
  • Nesin OM, Pakhomova ON, Xiao S, Pakhomov AG. Manipulation of cell volume and membrane pore comparison following single cell permeabilization with 60- and 600-ns electric pulses. Biochim Biophys Acta. 2011 Mar;1808(3):792-801. doi: 10.1016/j.bbamem.2010.12.012. Epub 2010 Dec 20. PMID: 21182825; PMCID: PMC3039094.
  • Ibey BL, Pakhomov AG, Gregory BW, Khorokhorina VA, Roth CC, Rassokhin MA, Bernhard JA, Wilmink GJ, Pakhomova ON. Selective cytotoxicity of intense nanosecond-duration electric pulses in mammalian cells. Biochim Biophys Acta. 2010 Nov;1800(11):1210-9. doi: 10.1016/j.bbagen.2010.07.008. Epub 2010 Aug 3. PMID: 20691249; PMCID: PMC2934740.
  • Bowman AM, Nesin OM, Pakhomova ON, Pakhomov AG. Analysis of plasma membrane integrity by fluorescent detection of Tl(+) uptake. J Membr Biol. 2010 Jul;236(1):15-26. doi: 10.1007/s00232-010-9269-y. Epub 2010 Jul 11. PMID: 20623351; PMCID: PMC2922847.
  • Ibey BL, Mixon DG, Payne JA, Bowman A, Sickendick K, Wilmink GJ, Roach WP, Pakhomov AG. Plasma membrane permeabilization by trains of ultrashort electric pulses. Bioelectrochemistry. 2010 Aug;79(1):114-21. doi: 10.1016/j.bioelechem.2010.01.001. Epub 2010 Jan 20. PMID: 20171148; PMCID: PMC2866803.
  • André FM, Rassokhin MA, Bowman AM, Pakhomov AG. Gadolinium blocks membrane permeabilization induced by nanosecond electric pulses and reduces cell death. Bioelectrochemistry. 2010 Aug;79(1):95-100. doi: 10.1016/j.bioelechem.2009.12.007. Epub 2009 Dec 24. PMID: 20097138; PMCID: PMC2866748.
  • Nuccitelli R, Chen X, Pakhomov AG, Baldwin WH, Sheikh S, Pomicter JL, Ren W, Osgood C, Swanson RJ, Kolb JF, Beebe SJ, Schoenbach KH. A new pulsed electric field therapy for melanoma disrupts the tumor’s blood supply and causes complete remission without recurrence. Int J Cancer. 2009 Jul 15;125(2):438-45. doi: 10.1002/ijc.24345. PMID: 19408306; PMCID: PMC2731679.
  • Pakhomov AG, Bowman AM, Ibey BL, Andre FM, Pakhomova ON, Schoenbach KH. Lipid nanopores can form a stable, ion channel-like conduction pathway in cell membrane. Biochem Biophys Res Commun. 2009 Jul 24;385(2):181-6. doi:10.1016/j.bbrc.2009.05.035. Epub 2009 May 18. PMID: 19450553; PMCID: PMC2739132.
  • Ibey BL, Xiao S, Schoenbach KH, Murphy MR, Pakhomov AG. Plasma membrane permeabilization by 60- and 600-ns electric pulses is determined by the absorbed dose. Bioelectromagnetics. 2009 Feb;30(2):92-9. doi: 10.1002/bem.20451. PMID: 18839412; PMCID: PMC2632729.
  • Joshi RP, Mishra A, Song J, Pakhomov AG, Schoenbach KH. Simulation studies of ultrashort, high-intensity electric pulse induced action potential block in whole-animal nerves. IEEE Trans Biomed Eng. 2008 Apr;55(4):1391-8. doi: 10.1109/TBME.2007.912424. PMID: 18390330.
  • Pakhomov AG, Kolb JF, White JA, Joshi RP, Xiao S, Schoenbach KH. Long-lasting plasma membrane permeabilization in mammalian cells by nanosecond pulsed electric field (nsPEF). Bioelectromagnetics. 2007 Dec;28(8):655-63. doi:10.1002/bem.20354. PMID: 17654532.
  • Pakhomov AG, Shevin R, White JA, Kolb JF, Pakhomova ON, Joshi RP, Schoenbach KH. Membrane permeabilization and cell damage by ultrashort electric field shocks. Arch Biochem Biophys. 2007 Sep 1;465(1):109-18. doi: 10.1016/j.abb.2007.05.003. Epub 2007 May 24. PMID: 17555703.
  • Walker K 3rd, Pakhomova ON, Kolb J, Schoenbach KS, Stuck BE, Murphy MR, Pakhomov AG. Oxygen enhances lethal effect of high-intensity, ultrashort electrical pulses. Bioelectromagnetics. 2006 Apr;27(3):221-5. doi: 10.1002/bem.20200. PMID: 16342277.

Book Chapters

  • Pakhomov, A., and Pakhomova, O. (2010). Nanopores: A distinct transmembrane passageway in electroporated cells.Advanced Electroporation Techniques in Biology in Medicine (pp. 178–194). Boca Raton: CRC Press.
  • Muratori, C., Casciola, M., Pakhomova, O. (2016) Electric pulse repetition rate: sensitization and desensitization. In:Miklavcic D (ed) Handbook of Electroporation. Springer International Publishing AG 2016, p.1-16. DOI: 10.1007/978-3-319-26779-1_23-1, ISBN: 978-3-319-26779-12.
  • Pakhomova, O., Gianulis E., Pakhomov, A. (2016) Different cell sensitivity to pulsed electric field. In: Miklavcic D (ed) Handbook of Electroporation. Springer International Publishing AG, 2016, p. 1-17. DOI: 10.1007/978-3-319-26779-1_22-1, ISBN: 978-3-319-26779-1.3.