Grants and Sponsored Research
Active
- “Nanoelectropulse-induced electromechanical signaling and control of biological systems” AFOSR MURI Topic 9, “Exploiting Biological Electromechanics: using Electromagnetic Energy to Control Biological Systems”, 10/01/2015-03/31/2022, $7,500,000
- “Mechanisms underlying the sensitivity of smooth muscle cells to NPS” Pulse Biosciences, 06/2021-05/2022 $250,000
- * “DNA-specific pattern recognition receptor activation following DNA electroporation” (PI L. Heller, U. of South Florida), R01CA196796, NIH (NCI) 02/01/2016 – 01/31/2021, $1,645,000.
- * “Activation of the Dendritic Cell-T Cell axis by nsPEF treatments” (PI C. Muratori) Pulse Biosciences,10/2019-09/2020, $300,000
- * “The contribution of ultrashort electric pulses in the induction of oxidative stress and assessment of the anticancer potential of nanosecond electroporation (nsPEF) in colon adenocarcinoma model in vitro and in vivo” (PI J. Kulbacka) National Centre of Science, Poland: SONATA BIS 6 ID:341885, No.: 2016/22/E/NZ5/00671 07/2017-06/2021, $450,000.
- * “The sensitization of pancreatic cancer cells to pulsed electric field and electrochemotherapy – from molecular modeling to miniaturized 3D cell cultures” (PI O. Michel) National Centre of Science, Poland: Preludium 14, ID:391244, No. PREL.A040.18.006, 09/2018 – 08/2021, $55,541.
Completed
2019-2020: “Minimizing Neuromuscular Excitation from NPS Ablation” Pulse Biosciences, $230,000
2015-2020: RO1HL128381 “Low Energy Defibrillation with Nanosecond Pulsed Electric Field” NIH/NHLBI, $1,509,283.
2018-2020: “Peripheral nerve stimulation with uni- and bipolar nanosecond pulses” Pulse Biosciences, $295,992
2018: Workshop on Fundamental and Applied Bioelectrics, Olympus, $2,500.
*2018-2019: “Nanosecond pulse stimulation to boost the immunogenicity of tumor cell death” Pulse Biosciences (PI: C. Muratori ) $264,000.
2017-2018: “Exploring Multimodal Cancer cell death induced by nsEP in vivo” Pulse Biosciences $154,000.
2014-2017: R21EB016912 “Picosecond pulse technology for non-invasive electrostimulation,” NIH (NIBIB), 03/01/2014 – 02/29/2017, $393,393. (Co-PIs: S. Xiao and A. Pakhomov).
2015-2016: “Improved tumor ablation by utilizing split dose protocols that engage electrosensitization” Electroblate, Inc. Task Order #2, 3/13/2015-3/12/2016, $349,750.
2015-2016: “High throughput in vitro testing of nanoelectroablation efficiency and apoptosis induction” Electroblate, Inc. Task Order #4, , $200,000.
2014-2015: “Cellular Effects of high amplitude electromagnetic pulses” Radio Frequency Bioeffects Branch/ GDIT DEBR II Program, Task Order #1, 7/10/2014-7/11/2015, $192,876.
*2010-2015: “Mechanisms and the impact of acetylated low density lipoprotein uptake on B cell functions”, EVMS-ODU collaborative grant Grant (PI: E. Galkina) 07/1/2014-06/30/2015. $12,000.
2010-2015: R01GM088303 “Mechanisms and Implications of Nanoelectroporation in Living Cells,” NIH (NIGMS), 07/01/2010 – 06/30/2015, $1,138,621.
*2013-2014: “Activatiojn of Cardiac Tissue with Nanosecond Pulsed Electric Fields,” ODU Office of Research Multidisciplinary Seed Funding (PI: C.Zemlin), 2013, 01/01/2013 – 12/01/2013, $50,000.
*2011-2013: “Investigation of field-dependent bioeffects of high amplitude electromagnetic pulses” Air Force Medical Support Agency (PI: Dr. B. Ibey), Dec 2011-2013, $1,730,000
2008-2013: R01CA125482 “Cell Death Induction by High-Voltage, Nanosecond-Duration Electric Pulses,” NIH (NCI), $1,078,970.
*2009-2012: “Mechanism of interaction between pulsed electric field and phospholipid bilayer membrane” AFOSR/LRIR (PI: B. Ibey), $623,000.
*2008-2009: “Neurological Impacts of Nanosecond Electric Pulse Exposure” (Co-PIs: B. Ibey and A. Pakhomov) HQAF SGRS Clinical Investigation Program 2008, Oct. 1, 2008 – Sept. 1, 2009, $100,000.
2007-2009: “A Comprehensive Study of Neuromuscular Effects of Nanosecond Electrical Pulses,” US DOD (ONR), March 16, 2007 – Dec. 31, 2009, $1,967,101.
2007-2009: “Effects of High-Peak-Power Electromagnetic Pulses on Cell Membrane,” AFRL,
Sept. 1, 2007 – May 30, 2009, $115,866.
*collaboration on grants awarded to other laboratories