{"id":884,"date":"2020-07-13T14:11:55","date_gmt":"2020-07-13T14:11:55","guid":{"rendered":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/?page_id=884"},"modified":"2020-07-13T17:09:55","modified_gmt":"2020-07-13T17:09:55","slug":"defibrillation-by-nsep","status":"publish","type":"page","link":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/defibrillation-by-nsep\/","title":{"rendered":"Defibrillation by nsEP"},"content":{"rendered":"\n<hr class=\"wp-block-separator\" \/>\n\n\n\n<p class=\"has-medium-font-size\">Sudden cardiac arrest, a major cause of death around the world, is most frequently caused by ventricular fibrillation, which can be terminated by a brief and intense electric shock. We study nsEP as a new modality to achieve higher efficiency of defibrillation on the first shock along with a profound reduction in the shock energy, minimized side effects, and low probability of reentry arrhythmias. Experiments in Langendorff-perfused rabbit hearts (together with C. Zemlin) supported the efficiency and safety of nsEP for defibrillation. We continue with studying mechanisms of excitation and damage of cardiomyocytes by nsEP and compare the effects to conventional (long) pulses.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-content\/uploads\/sites\/19252\/2020\/07\/defib-1024x375.png\" alt=\"\" class=\"wp-image-885\" width=\"722\" height=\"264\" srcset=\"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-content\/uploads\/sites\/19252\/2020\/07\/defib-1024x375.png 1024w, https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-content\/uploads\/sites\/19252\/2020\/07\/defib-300x110.png 300w, https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-content\/uploads\/sites\/19252\/2020\/07\/defib-150x55.png 150w, https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-content\/uploads\/sites\/19252\/2020\/07\/defib-768x282.png 768w, https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-content\/uploads\/sites\/19252\/2020\/07\/defib-1536x563.png 1536w, https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-content\/uploads\/sites\/19252\/2020\/07\/defib-2048x751.png 2048w, https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-content\/uploads\/sites\/19252\/2020\/07\/defib-800x293.png 800w\" sizes=\"(max-width: 722px) 100vw, 722px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Sudden cardiac arrest, a major cause of death around the world, is most frequently caused by ventricular fibrillation, which can be terminated by a brief and intense electric shock. We study nsEP as a new modality to achieve higher efficiency &hellip; <a href=\"https:\/\/sites.wp.odu.edu\/pakhomovlab\/defibrillation-by-nsep\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":17520,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-json\/wp\/v2\/pages\/884"}],"collection":[{"href":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-json\/wp\/v2\/users\/17520"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-json\/wp\/v2\/comments?post=884"}],"version-history":[{"count":4,"href":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-json\/wp\/v2\/pages\/884\/revisions"}],"predecessor-version":[{"id":968,"href":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-json\/wp\/v2\/pages\/884\/revisions\/968"}],"wp:attachment":[{"href":"https:\/\/sites.wp.odu.edu\/pakhomovlab\/wp-json\/wp\/v2\/media?parent=884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}