{"id":386,"date":"2024-02-18T20:13:31","date_gmt":"2024-02-18T20:13:31","guid":{"rendered":"https:\/\/sites.wp.odu.edu\/thetienvo\/?p=386"},"modified":"2024-02-18T20:13:31","modified_gmt":"2024-02-18T20:13:31","slug":"igm-drawing","status":"publish","type":"post","link":"https:\/\/sites.wp.odu.edu\/thetienvo\/2024\/02\/18\/igm-drawing\/","title":{"rendered":"IgM Drawing"},"content":{"rendered":"\n<p class=\"has-text-align-center\"><img loading=\"lazy\" decoding=\"async\" width=\"624\" height=\"343\" src=\"https:\/\/lh7-us.googleusercontent.com\/ysXjrviIhpWtSabyFo7BQFLPRWMoRNbuzNl5V2oNwN4OIE8qhpQWIdyekG2LT0BXQLJmHmhRUfSlLuRphwwXl2S9L0cYL7KlW5soX55eZsb4WOQn4pEZjiNrZzRxv0slk_joP4S_pBbqtTZoPTzA-mQ\"><\/p>\n\n\n\n<p class=\"has-text-align-left\">My drawing of the IgM-BCR contains two heavy chains, two light chains, and an Ig\u03b1\/Ig\u03b2 heterodimer. The drawing also contains 14 glycosylation sites, additional labels of Fab, the constant and variable regions, and the Ig-like extracellular domains (ECD). The IgM-BCR is crucial for the development and activation of B cells. Its ability to detect antigens with help from the plasma membrane also plays a role in recognizing antigens with the cluster of BCRs interacting with the extracellular domain and the intracellular membrane. The molecule differs from the soluble pentameric IgM due to their structural variations. The soluble pentameric IgM contains two C-terminal \u03b2 strands of the C\u03bc4 that mediate oligomerization. In contrast, the C\u03bc4 of the IgM-BCR has C-terminal \u03b1 strands and transmembrane helices (TM\u03bc<sub>A<\/sub> and TM\u03bc<sub>B<\/sub>) anchor the receptor onto the cell membrane.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>My drawing of the IgM-BCR contains two heavy chains, two light chains, and an Ig\u03b1\/Ig\u03b2 heterodimer. The drawing also contains 14 glycosylation sites, additional labels of Fab, the constant and variable regions, and the Ig-like extracellular domains (ECD). The IgM-BCR is crucial for the development and activation of B cells. Its ability to detect antigens&#8230; <\/p>\n<div class=\"link-more\"><a href=\"https:\/\/sites.wp.odu.edu\/thetienvo\/2024\/02\/18\/igm-drawing\/\">Read More<\/a><\/div>\n","protected":false},"author":24670,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","wds_primary_category":0},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/posts\/386"}],"collection":[{"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/users\/24670"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/comments?post=386"}],"version-history":[{"count":1,"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/posts\/386\/revisions"}],"predecessor-version":[{"id":387,"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/posts\/386\/revisions\/387"}],"wp:attachment":[{"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/media?parent=386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/categories?post=386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.wp.odu.edu\/thetienvo\/wp-json\/wp\/v2\/tags?post=386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}