Activation of Voltage-Gated Calcium Channels (VGCC) by nsEP
Nanosecond pulses may be too brief to cause translocation of the voltage sensor of VGCC and channel opening. Instead, nsEP can electroporate the membrane, causing depolarization due the loss of the resting membrane potential, which will culminate in the VGCC opening.
This project aims to establish if VGCC can be activated by nsEP directly, without the concurrent membrane damage by electroporation.
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